HIPEC and EPIC Protocols PDF Print E-mail
 

Adenocarcinoma of the appendix (including PMP)

 

Agent

Mitomycin C

 

Dose

15mg/m2

At time 0

2nd Dose

5mg/m2

At 45 minutes

Perfusion duration

90 minutes

 

Inflow Temp.

44°C

 

 

Adenocarcinoma of the colon (Protocol #1)

 

Agnet-1

I.V 5Flourouracil

10 minutes before perfusion

Dose

400mg/m2

 

 

I.V Leucovorin

60 minutes before perfusion

Dose

20mg/m2

 

Agent-2

Mitomycin C

 

Dose

15mg/m2

At time 0

2nd Dose

5mg/m2

At 45 minutes

Perfusion duration

90 minutes

 

Inflow Temp.

44°C

 

 

 

Adenocarcinoma of the colon (Protocol #2)

 

 

Agnet-1

I.V 5Flourouracil

10 minutes before perfusion

Dose

400mg/m2

 

 

I.V Leucovorin

60 minutes before perfusion

Dose

20mg/m2

 

Agent-2

Oxaliplatin

( in D5W)

Dose

460mg/m2

At time 0

Perfusion duration

60 minutes

 

Inflow Temp.

44°C

 

 

Early Post Operative Chemotherapy (EPIC) Protocol for adenocarcinoma of the colon or rectum

 

The HIPEC catheters are left after surgery connected to close suction drains. I.P chemotherapy is delivered through the inflow catheter while all outflow catheters are clamped.

I.P 5-fluorouracil 650mg/m2 is administrated 1 hour after the administration of IV Leucovorin 20mg/m2.


The I.P 5-fluorouracil is delivered slowly over one hour to avoid abdominal pain and distension. All outflow catheters remain closed for additional 4 hours.

The treatment repeated 5 times and daily basis form POD#1-5 depending on the patient's status as evaluated by the surgical and ICU teams.